The Wales Josh Adams wing was excluded from the six nations journey to confront Scotland in Morafield on Saturday.
Cardiff Wing Adams, 29, missed a 27-18 loss against Ireland in Cardiff with a problem with the knee strings and did not recover in time at the end of this week.
Gloucester Fly-Half Gareth Anscombe has recovered from a header suffered against Ireland and is available for selection.
Ospreys Hooker Dewi Lake is also competing to return after it lost the defeat of the first six countries due to an arm injury.
Wales lost 15 standard test matches in a row with temporary coach Matt Sherat from Warren Gatland before Ireland's defeat.
