Gloucester has three beginners in Wales with ANSCOCOBE join SCRUM-Half Tomos Williams and Center Max Llewelyn.
Josh Hathaway and Fredi Thomas are also in the team, while striker Rais Thomas coach participated in the background staff.
England will reach the emirate's stadium as a competitor for the title, although France's victory at a bonus point against Scotland later on Saturday night will guarantee Leg Plaos.
Anscombe admits that Wales's victory will give him some bragging rights when players return to Gloucester.
“It will make it a little more fun,” Anscombe said.
“You don't need to build this game and England comes here with an opportunity to do something too.
“England on the field is always a little different. We know that there is a great sensation and we all want to give the fans something joy.”
The future of Anscombe in Kingsholm is not certain after only one season, with Ross Bern's signature in Ireland on Gloucester.
Anscombe said: “The six countries are a unique competition and come in the middle of the road. They were complete during the past three weeks. We are just trying to play the game and what to change.”
“My only focus was to enjoy moving to the red shirt because when you reach my life, you do not know how many times you will get a chance.
“For me, she is enjoying the moment, playing with Wales and I will see me in the future in the next few weeks.”
