British Josh Tarling and former hero Breeze Rojik gave up Jiro de Italy after his disruption in the 16th dramatic stage.
Isaac del Toro clung to the captain's pink shirt, but he cut greatly by British Simon Yates and Richard Karabaz, who walked in third place.
Christian Scaroni won in Italy on the stage of Sol Pesola Sol Brent to San Valentino after he ended up in the final rise with his teammate XDS Astana and his compatriot Lorenzo Fortonato, who finished second.
Wilcheman Tarling, 21, slipped on a wet surface early on Tuesday and suffered from severe crash into a barrier.
The Slovenian Roglic, one of the pre -race preferences, was broken shortly after a slippery descending alongside the Ecuador Carabaz.
Roglic, 35, tried to last shortly before going up to the Red Bull-Pora-Hansgrohe team.
The winner in 2023 suffered from his third crash in the week on Saturday and lost the decisive time for his competitors in the general classification in the 15th stage on Sunday.
However, the 2019 award -winning Karabaz recovered from his fall to launch a strong attack late to leave Del Toro and Whites.
Yetz responded with his own attack to drop Mexico del Toro, who managed to fight in order to stick to the race.
Del Toro, the UAE team in the UAE, is leading Visma-Ereease, 26 seconds, with Carapaz of Ef Eduction-Easypost just five seconds.
Derek Ji from Canada has also occupied a time in Del Toro in fourth place, a minute of Karabaz.
Juan Ayou from Spain, a teammate of Del Toro and another of the preferred candidates before the race, cracked and lost a great time to fall from the top ten, after he started today in third place.
Yetz twin brother Adam moved to the tenth place in general, with his British colleagues Max Paul (13), Tom Bidkok (16) and James Nox (19) within the best 20.
Stage 17 on Wednesday is another day in the mountains of San Michel Clendig to Burmio.
