Lancashire separates a company with Dale Benkenstein for men with an immediate effect through mutual approval.
South Africa, 50, is leaving with Lancashire in second place in the second section of the province championship, after it landed from the highest trip last season.
They are the only club in any of the two sections they did not win the game of the championship this summer.
The former Stephen Coft was named ROD Rose Cort as a major coach for men, with the help of Will Porterfield, Craig White and Karl Krikken.
The first match for Croft will be the opening match of Lancashire's T20 Blast at home to Worlestershire Rapids in the Emirates Old Trafford on Thursday (18:30 GMT).
