Shepherd, which played 37 ODIS and 53 T20S, will be replaced by the team by Seamer Jediah Blades.
He played four games with Royal Challengers Bengaluru in IPL, including 14 53 balls not in his latest roles.
Radford played in nine matches for the current IPL leaders, Gujarat Jogharat this season.
It will be replaced by the first -class mixture, John Campbell, to attend the Ireland leg from the tour, while Shimron Hater will take his place in matches against England.
Hetmyer is another player in the West Indies in the IPL but his team Rajasthan Royals has already been eliminated. It was originally left from Windies Odi after a weak run of shape.
SEAMER SHAMAR Joseph is in IPL but he did not show his LuckNow Super Giants and remains in the West Indies team.
Windies plays three Odis in Ireland from May 21 before a series of three games in England from May 29.
Three T20s against England is affiliated with June 6, but tourists have never named a team for that competition.
